Differences in local population history at the finest level: the case of the Estonian population.

ABSTRACT: Several recent studies detected fine-scale genetic structure in human populations. Hence, groups conventionally treated as single populations harbour significant variation in terms of allele frequencies and patterns of haplotype sharing. It has been shown that these findings should be considered when performing studies of genetic associations and natural selection, especially when dealing with polygenic phenotypes. However, there is little understanding of the practical effects of such genetic structure on demography reconstructions and selection scans when focusing on recent population history. Here we tested the impact of population structure on such inferences using high-coverage (~30×) genome sequences of 2305 Estonians. We show that different regions of Estonia differ in both effectiv

SUBMITTER: Pankratov V 

PROVIDER: S-EPMC7575549 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature