The transcription factor Sox10 is an essential determinant of branching morphogenesis and involution in the mouse mammary gland.

ABSTRACT: The high mobility group-domain containing transcription factor Sox10 is an essential regulator of developmental processes and homeostasis in the neural crest, several neural crest-derived lineages and myelinating glia. Recent studies have also implicated Sox10 as an important factor in mammary stem and precursor cells. Here we employ a series of mouse mutants with constitutive and conditional Sox10 deficiencies to show that Sox10 has multiple functions in the developing mammary gland. While there is no indication for a requirement of Sox10 in the specification of the mammary placode or descending mammary bud, it is essential for both the prenatal hormone-independent as well as the pubertal hormone-dependent branching of the mammary epithelium and for proper alveologenesis during pregnancy.

SUBMITTER: Mertelmeyer S 

PROVIDER: S-EPMC7575560 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature