A novel PET tracer ¹⁸F-deoxy-thiamine: synthesis, metabolic kinetics, and evaluation on cerebral thiamine metabolism status.

ABSTRACT:

Background

Some neuropsychological diseases are associated with abnormal thiamine metabolism, including Korsakoff-Wernicke syndrome and Alzheimer's disease. However, in vivo detection of the status of brain thiamine metabolism is still unavailable and needs to be developed.

Methods

A novel PET tracer of ¹⁸F-deoxy-thiamine was synthesized using an automated module via a two-step route. The main quality control parameters, such as specific activity and radiochemical purity, were evaluated by high-performance liquid chromatography (HPLC). Radiochemical concentration was determined by radioactivity calibrator. Metabolic kinetics and the level of ¹⁸F-deoxy-thiamine in brains of mice and marmosets were studied by micro-positron emission tomography/computed to

SUBMITTER: Wang C 

PROVIDER: S-EPMC7575681 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature