The relationship between KRAS gene mutation and intestinal flora in tumor tissues of colorectal cancer patients.

ABSTRACT:

Background

Colorectal cancer is among the most prominent malignant tumors endangering human health, with affected populations exhibiting an increasingly younger trend. The Kirsten ras (KRAS) gene acts as a crucial regulator in this disease and influences multiple signaling pathways. In the present study, the KRAS gene mutation-induced alteration of intestinal flora in colorectal cancer patients was explored, and the intestinal microbes that may be affected by the KRAS gene were examined to provide new insights into the diagnosis and treatment of colorectal cancer.

Methods

Deoxyribonucleic acid (DNA) was extracted from 177 colorectal cancer patients in our hospital. The mutation of the KRAS gene was subsequently detected using real-time fluo

SUBMITTER: Sui X 

PROVIDER: S-EPMC7575961 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature