The profiles of biopsy-proven renal tubulointerstitial lesions in patients with glomerular disease.

ABSTRACT:

Background

Renal tubules and interstitium are vulnerable to injury and play a central role in the progression of various chronic kidney diseases (CKDs). However, high quality epidemiologic study on the profiles of biopsy-proven tubulointerstitial lesions (TILs) is extremely limited.

Methods

We conducted a retrospective renal biopsy series including 62,569 native biopsies at 1,211 hospitals across China from 2015 to 2017. The TILs, including the shedding of tube epithelial, renal tubular atrophy, renal interstitial fibrosis, edema and inflammatory infiltration, were identified from the pathological report. We analyzed the severity and chronicity of TILs stratified by gender, age groups, biopsy indications, and concurrent glomerular diseases. We also examined the correlation b

SUBMITTER: Dong J 

PROVIDER: S-EPMC7575977 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature