The effect of intestinal flora on immune checkpoint inhibitors in tumor treatment: a narrative review.

ABSTRACT: Tremendous progress has been achieved in understanding of the interaction between tumor microenvironment and intestinal flora in the past decades. Immune checkpoint inhibitors (ICIs) are a promising treatment strategy for advanced tumors, most prominently cytotoxic T-lymphocyte-associated protein (CTLA-4) and programmed cell death protein-1 (PD-1), its major ligand PD-L1, its beneficial to part of the population and obtaining excellent clinical results. However, the majority of patients do not respond or develop early progressive disease. Reached consensus by experts currently believe that the intestinal flora plays an important role in the explanation of the limited therapeutic effect of ICIs, there are differences in the composition of intestinal flora between patients with good response

SUBMITTER: Wang D 

PROVIDER: S-EPMC7575978 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature