Locoregional gastric cancer: a narrative review of multidisciplinary management.

ABSTRACT: Gastric cancer is one of the most common cancers worldwide. While relatively uncommon in the United States, worldwide it is the 5^th most common cancer diagnosed. Almost half of patients present with locoregional disease. Even with advanced surgical techniques and adjuvant perioperative treatment the prognosis for patients in this cohort is still dismal. Perioperative chemotherapy and/or radiation have been used in the last several decades in an attempt to improve outcomes in locally advanced resectable gastric cancer. In this article, we will review the development of these multimodal treatment strategies over the past two to three decades. We will compare these treatment modalities and their impact on survival outcomes. We will review the evidence for perioperative chemotherapy

SUBMITTER: Pelcovits A 

PROVIDER: S-EPMC7575982 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature