Analysis of 2019-nCoV receptor ACE2 expression in different tissues and its significance study.

ABSTRACT:

Background

On March 11, 2020, the World Health Organization (WHO) officially announced that the coronavirus disease 2019 (COVID-19) had reached global pandemic status. Current studies have found that angiotensin-converting enzyme 2 (ACE2) is a cell surface receptor of the novel coronavirus that plays a vital role in the pathogenesis of COVID-19. It is of immense importance for the prevention of virus transmission and treatment to clarify the distribution and expression of ACE2 in various tissues and organs of the body.

Methods

RNAseq transcriptome data and sex data were obtained from the genotype-tissue expression (GTEx) and the Cancer Genome Atlas (TCGA) databases. We separately analyzed the distribution of ACE2 expression in different tissues in the GTEx and TCGA database,

SUBMITTER: Han T 

PROVIDER: S-EPMC7576005 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature