Toll-like receptors 2 expression in mediastinal lymph node of patients with sarcoidosis.

ABSTRACT:

Background

Toll-like receptors (TLRs) play a vital role as a first defense mechanism linking the innate with the adaptive immune system. Prior studies showed that TLR2 participated in immune responses of sarcoidosis. However, the role of TLR2 in the progression of mediastinal lymph nodes associated with sarcoidosis is still unknown. The current study aims to investigate the expression of Toll-like receptors 2 (TLR2) in mediastinal lymph nodes of patients with sarcoidosis.

Methods

Mediastinal lymph nodes biopsy specimens were collected from 10 patients with sarcoidosis and 11 normal controls. The expression of TLR2 in mediastinal lymph nodes was detected by immunohistochemistry.

Results

In mediastinal lymph nodes specimens, immunohistochemical examination revealed that

SUBMITTER: Chen X 

PROVIDER: S-EPMC7576029 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature