METTL7B (methyltransferase-like 7B) identification as a novel biomarker for lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is still one of the major causes of cancer-related mortality across the globe. Therefore, there is a dire need to identify early specific and sensitive biomarkers or drug targets of LUAD for developing improved diagnosis and clinical management. We aimed to investigate the role of methyltransferase-like 7B (METTL7B) on LUAD tumor development and progression in this study.

Methods

METTL7B's expression was confirmed in two independent clinical cohort samples, including LUAD tissues microarray (TMA) via immunohistochemistry (IHC) and serum samples via enzyme-linked immunosorbent assay (ELISA). The correlation between METTL7B expression with clinicopathological features and overall survival rate in LUAD patients was then further analyzed. Me

SUBMITTER: Ali J 

PROVIDER: S-EPMC7576055 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature