Development and validation of a prognostic and immunotherapeutically relevant model in hepatocellular carcinoma.

ABSTRACT:

Background

The tumor immune microenvironment is pivotal in predicting clinical outcomes and therapeutic efficacy in cancer patients. This study aims to develop an immune prediction model (IPM) to effectively predict prognosis and immunotherapeutic response in patients with hepatocellular carcinoma (HCC).

Methods

An IPM was constructed and validated based on immune-related genes. The influence of IPM on the HCC immune microenvironment, as well as the possible mechanism, was comprehensively analyzed. The value of the model in predicting the response of HCC patients to immunotherapy was also evaluated.

Results

A novel IPM based on eight genes was developed and validated to predict the prognosis of HCC patients. These genes are matrix metalloproteinase 12 (MMP12), heme ox

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7576066 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature