Association of high-risk human papillomavirus infection duration and cervical lesions with vaginal microbiota composition.

ABSTRACT:

Background

Cervical cancer is reportedly caused by the synergistic effects of persistent high-risk human papillomavirus (HPV) infection. Cervical microbiota represent a unique and dynamically changing microecological system that is directly exposed to the vagina. The relationship between HPV and the composition of the cervical microbiome has long been a primary focus of research.

Methods

To determine the specific differential florae throughout the process of cervical cancer development, in the present study, 16S rRNA sequencing was combined with KEGG pathway enrichment analysis to analyse five groups of cervical scraping samples with increasing durations of HPV infection and cervical intraepithelial neoplasia pathological classification.

Results

The findings revealed

SUBMITTER: Liu J 

PROVIDER: S-EPMC7576078 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature