Exploration of microRNA profiles in human colostrum.

ABSTRACT:

Background

Colostrum is well known to have excellent nutritional value for newborns. The aim of this study was to investigate the dynamic expression pattern of microRNA in human colostrum and mature milk. Furthermore, we identified the specific microRNA in human colostrum and analyzed the regulatory function of human colostrum.

Methods

We collected breast milk samples from 18 lactating volunteers. The expression of microRNA in breast milk was detected by microarray analysis. The expression differences were characterized by log2FC (|log2fold change| >1.58) and associated P values (P<0.05). Furthermore, the prediction of microRNA targets, bioinformatics analysis and network generation were carried out using network database.

Results

Our results showed that during the hu

SUBMITTER: Wu F 

PROVIDER: S-EPMC7576086 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature