Ontology highlight
ABSTRACT:
SUBMITTER: Craig JE
PROVIDER: S-EPMC7576125 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cell death discovery 20201020
Mitochondria are vital organelles that coordinate cellular energy homeostasis and have important roles in cell death. Therefore, the removal of damaged or excessive mitochondria is critical for maintaining proper cellular function. The PINK1-Parkin pathway removes acutely damaged mitochondria through a well-characterized mitophagy pathway, but basal mitochondrial turnover occurs via distinct and less well-understood mechanisms. Here we report that the MEKK3-MEK5-ERK5 kinase cascade is required f ...[more]