Diversity of voltage-gated potassium channels and cyclic nucleotide-binding domain-containing channels in eukaryotes.

ABSTRACT: Voltage-gated potassium channels (K_v) and cyclic nucleotide-binding domain-containing cation channels HCN, CNG, and KCNH are the evolutionarily related families of ion channels in animals. Their homologues were found in several lineages of eukaryotes and prokaryotes; however, the actual phylogenetic and structural diversity of these ion channels remains unclear. In this work, we present a taxonomically broad investigation of evolutionary relationships and structural diversity of K_v, HCN, CNG, and KCNH and their homologues in eukaryotes focusing on channels from different protistan groups. We demonstrate that both groups of channels consist of a more significant number of lineages than it was shown before, and these lineages can be grouped in two clusters termed K

SUBMITTER: Pozdnyakov I 

PROVIDER: S-EPMC7576140 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature