Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats.

ABSTRACT: As demonstrated by increased hippocampal insulin receptor density following learning in animal models and decreased insulin signaling, receptor density, and memory decline in aging and Alzheimer's diseases, numerous studies have emphasized the importance of insulin in learning and memory processes. This has been further supported by work showing that intranasal delivery of insulin can enhance insulin receptor signaling, alter cerebral blood flow, and improve memory recall. Additionally, inhibition of insulin receptor function or expression using molecular techniques has been associated with reduced learning. Here, we sought a different approach to increase insulin receptor activity without the need for administering the ligand. A constitutively active, modified human insulin receptor (IRβ)

SUBMITTER: Frazier HN 

PROVIDER: S-EPMC7576226 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature