Mechanisms underlying familial aggregation of exceptional health and survival: A three-generation cohort study.

ABSTRACT: The familial resemblance in length of adult life is very modest. Studies of parent-offspring and twins suggest that exceptional health and survival have a stronger genetic component than lifespan generally. To shed light on the underlying mechanisms, we collected information on Danish long-lived siblings (born 1886-1938) from 659 families, their 5379 offspring (born 1917-1982), and 10,398 grandchildren (born 1950-2010) and matched background population controls through the Danish 1916 Census, the Civil Registration System, the National Patient Register, and the Register of Causes of Death. Comparison with the background, population revealed consistently lower occurrence of almost all disease groups and causes of death in the offspring and the grandchildren. The expected incidence of hospit

SUBMITTER: Christensen K 

PROVIDER: S-EPMC7576291 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature