Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion.

ABSTRACT: Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5%-10% of mutations in BRCA genes are associated with familial breast tumours in Eastern countries, suggesting the contribution of other genes. Using a microarray gene expression profiling study of BC, we have recently identified BRIP1 (fivefold up-regulation) as a potential gene associated with BC progression in the Omani population. Although BRIP1 regulates DNA repair and cell proliferation, the precise role of BRIP1 in BC cell invasion/metastasis has not been explored yet; this prompted us to test the hypothesis that BRIP1 promotes BC cell proliferation and invasion. Using a combination of cellular and molecular approaches, our results revealed differential overexpression of BRIP1 in

SUBMITTER: Rizeq B 

PROVIDER: S-EPMC7576304 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature