Network Pharmacology Identifies the Mechanisms of Sang-Xing-Zhi-Ke-Fang against Pharyngitis.

ABSTRACT:

Background

Sang-Xing-Zhi-Ke-Fang (SXZKF) demonstrates good therapeutic effect against pharyngitis. Nevertheless, the pharmacological mechanism underlying its effectiveness is still unclear.

Objective

To investigate the underlying mechanisms of SXZKF against pharyngitis using network pharmacology method.

Methods

Bioactive ingredients of SXZKF were collected and screened using published literature and two public databases. Using four public databases, the overlapping genes between these bioactive compound-related and pharyngitis-related genes were identified by Venn diagram. Protein-protein interaction (PPI) was obtained using "Search Tool for the Retrieval of Interacting Genes (STRING)" database. "Database for Annotation, Visualization, and Integrated Discovery ver. 6.

SUBMITTER: Deng Y 

PROVIDER: S-EPMC7576344 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature