Long-term risk of hip or forearm fractures in older occasional users of benzodiazepines.

ABSTRACT:

Aims

This article sought to study the association between patterns of benzodiazepine (BZD) use and the risk of hip and forearm fractures in people aged 50 and 75 years or more.

Methods

In a representative cohort of the French National Health Insurance Fund of individuals aged 50 years or older (n = 106 437), we followed up BZD dispensing (reflecting their patterns of use) and the most frequent fall-related fractures (hip and forearm) for 8 years. We used joint latent class models to simultaneously identify BZD dispensing trajectories and the risk of fractures in the entire cohort and in those 75 years or older). We used a survival model to estimate the adjusted hazard ratios (aHRs) between these trajectories and the risk of fractures.

Results

In the entire cohort, we

SUBMITTER: Carrier H 

PROVIDER: S-EPMC7576621 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature