Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers.

ABSTRACT:

Aims

The aim of this study was to investigate the effects of a single green tea (GT), administered concomitantly or 1 hour before nadolol intake on nadolol pharmacokinetics.

Methods

In a randomized 3-phase crossover study, 11 healthy volunteers received an oral administration of nadolol with, or 1 hour after preingestion of brewed GT, or with water in a volume of 150 mL.

Results

Geometric mean ratio with 90% confidence interval for nadolol AUC_0-48 was 0.371 (0.303-0.439) with concomitant GT. In addition, ingestion of GT 1 hour before nadolol administration resulted in a significant reduction of nadolol AUC_0-48 with geometric mean ratio of 0.536 (0.406-0.665). There were no differences in time to maximal plasma concentration and renal clearance of

SUBMITTER: Misaka S 

PROVIDER: S-EPMC7576630 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature