Use of antipsychotics and the risk of acute respiratory failure among adults: A disease risk score-matched nested case-control study.

ABSTRACT:

Aims

Evidence on acute respiratory failure (ARF) from antipsychotics is scant, and only 1 population-based study examined this drug safety issue in chronic obstructive pulmonary disease patients. Antipsychotics have been frequently prescribed off-label in adults, but whether antipsychotic use carries an increased ARF risk among adult patients is uncertain.

Methods

We adopted a nested case-control study analysing 716 493 adults aged ≥20 years, identified from the Taiwan nationwide healthcare claims records between January 2000 and December 2013. Among the study cohort, 7084 adults with ARF and 12,785 disease risk scored-matched randomly selected controls were analysed. Multivariable logistic regression models were employed to estimate odds ratios of ARF with antipsychotic usa

SUBMITTER: Wang MT 

PROVIDER: S-EPMC7576632 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature