The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study.

ABSTRACT:

Aims

Older patients in particular suffer from adverse drug reactions (ADR) when presenting in the emergency department. We aimed to characterise the phenotype of those ADRs, to be able to recognise an ADR in older patients.

Methods

Cases of ADRs in emergency departments collected within the multicentre prospective observational study (ADRED) were analysed (n = 2215). We analysed ADR-associated diagnoses, symptoms and their risk profiles. We present frequencies and odds ratios (OR) with 95% confidence intervals for adults (18-64 years) compared to older adults (≥65 years; young-old 65-79, old-old ≥80 years) and regression coefficients (B) for each year of age.

Results

Most prominent differences were seen for drug-associated confusion, dehydration, and bradycardia (OR 6

SUBMITTER: Just KS 

PROVIDER: S-EPMC7576634 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature