Effect of acute citalopram on self-referential emotional processing and social cognition in healthy volunteers.

ABSTRACT:

Background

Depression is characterised by negative views of the self. Antidepressant treatment may remediate negative self-schema through increasing processing of positive information about the self. Changes in affective processing during social interactions may increase expression of prosocial behaviours, improving interpersonal communications.

Aims

To examine whether acute administration of citalopram is associated with an increase in positive affective learning biases about the self and prosocial behaviour.

Method

Healthy volunteers (n = 41) were randomised to either an acute 20 mg dose of citalopram or matched placebo in a between-subjects double-blind design. Participants completed computer-based cognitive tasks designed to measure referential affective processin

SUBMITTER: Hobbs C 

PROVIDER: S-EPMC7576669 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature