Association of circulating inflammation proteins and gallstone disease.

ABSTRACT:

Background and aim

Inflammation plays a role in the development of both gallstones and gallbladder cancer; however, few studies have investigated the association of circulating inflammation proteins with risk of gallstones.

Methods

This study measured 13 cytokines (including 10 interleukins [ILs]) that have been associated with cancer in serum samples collected from 150 gallstone patients and 149 population-based controls from Shanghai, China, in 1997-2001. This study estimated the associations of each cytokine, categorized into quartiles and coded as a trend, with risk of gallstones using logistic regression models adjusted for potential confounders.

Results

Higher levels of IL-6, IL-10, IL-12 (p70), and IL-13 were associated with increased risk of gallstones (i.e. P

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7576672 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature