Bioengineered human skeletal muscle capable of functional regeneration.

ABSTRACT:

Background

Skeletal muscle (SkM) regenerates following injury, replacing damaged tissue with high fidelity. However, in serious injuries, non-regenerative defects leave patients with loss of function, increased re-injury risk and often chronic pain. Progress in treating these non-regenerative defects has been slow, with advances only occurring where a comprehensive understanding of regeneration has been gained. Tissue engineering has allowed the development of bioengineered models of SkM which regenerate following injury to support research in regenerative physiology. To date, however, no studies have utilised human myogenic precursor cells (hMPCs) to closely mimic functional human regenerative physiology.

Results

Here we address some of the difficulties associated with cell

SUBMITTER: Fleming JW 

PROVIDER: S-EPMC7576716 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature