Physiological effects of different recruitment maneuvers in a pig model of ARDS.

ABSTRACT:

Background

In acute respiratory distress syndrome (ARDS), lung recruitment maneuvers can recruit collapsed alveoli in gravity-dependent lung regions, improving the homogeneity of ventilation distribution. This study used electrical impedance tomography to investigate the physiological effects of different recruitment maneuvers for alveolar recruitment in a pig model of ARDS.

Methods

ARDS was induced in ten healthy male pigs with repeated bronchoalveolar lavage until the ratio of arterial partial pressure of oxygen (PaO₂) of fraction of inspired oxygen (P/F) was < 100 mmHg and remained stable for 30 min (T_ARDS). ARDS pigs underwent three sequential recruitment maneuvers, including sustained inflation, increments of positive end-expiratory pressure (PEEP)

SUBMITTER: Xia F 

PROVIDER: S-EPMC7576861 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature