Voltage-Dependent Dopamine Potency at D₁-Like Dopamine Receptors.

ABSTRACT: In recent years, transmembrane voltage has been found to modify agonist potencies at several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the Gα_i/o-coupled dopamine D₂-like receptors (D₂R, D₃R, D₄R) have previously been investigated, the putative impact of transmembrane voltage on agonist potency at the mainly Gα_s/olf-coupled dopamine D₁-like receptors (D₁R, D₅R) has hitherto not been reported. Here, we assayed the potency of dopamine in activating G protein-coupled inward rectifier potassium (GIRK) channels co-expressed with D₁R and D₅R in Xenopus oocytes, at -80 mV and at 0 mV. Furthermore, GIRK response deactivation rates upon dopam

SUBMITTER: Agren R 

PROVIDER: S-EPMC7577048 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature