Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review.
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ABSTRACT:
SUBMITTER: Bai AD
PROVIDER: S-EPMC7577162 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review.
Bai Anthony D AD Komorowski Adam S AS Lo Carson K L CKL Tandon Pranav P Li Xena X XX Mokashi Vaibhav V Cvetkovic Anna A Findlater Aidan A Liang Laurel L Loeb Mark M Mertz Dominik D
Antimicrobial agents and chemotherapy 20201020 11
Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Our systematic review of 175 noninferiority antibiotic trials found these scenarios to be rare. ...[more]
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