Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study.

ABSTRACT:

Importance

Observational studies highlight associations of C-reactive protein (CRP), a general marker of inflammation, and interleukin 6 (IL-6), a cytokine-stimulating CRP production, with individual depressive symptoms. However, it is unclear whether inflammatory activity is associated with individual depressive symptoms and to what extent metabolic dysregulation underlies the reported associations.

Objective

To explore the genetic overlap and associations between inflammatory activity, metabolic dysregulation, and individual depressive symptoms.

Gwas data sources

Genome-wide association study (GWAS) summary data of European individuals, including the following: CRP levels (204 402 individuals); 9 individual depressive symptoms (3 of which did not differentiate betwe

SUBMITTER: Kappelmann N 

PROVIDER: S-EPMC7577200 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature