Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.

ABSTRACT: A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior. Engagement of FCGRT with the crystallizable fragment (Fc) domain protects IgG from catabolic elimination, thereby extending the persistence and bioavailability of IgG and related Fc-based biologics. There is a need for reliable in vivo models to facilitate the preclinical development of novel IgG-based biologics. FcRn-humanized mice have been widely accepted as translationally relevant surrogates for IgG-based biologics evaluations. Although such FCGRT-humanized mice, especially the mouse strain, B6.Cg-Fcgrt^tm1Dcr Tg(FCGRT)32Dcr (abbreviated Tg32), have been substantial

SUBMITTER: Low BE 

PROVIDER: S-EPMC7577234 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature