Looking for answers: the current status of neoadjuvant treatment in localized soft tissue sarcomas.

ABSTRACT:

Purpose

Sarcomas are a rare and heterogeneous variant of cancer. The standard of care treatment involves surgical resection with radiation in high-risk patients. Despite appropriate treatment approximately 50 % of patients will suffer and die from recurrent disease. The purpose of this article is to review the current evidence concerning the use of neoadjuvant chemotherapy with or without radiation in soft tissue sarcomas.

Methods

An in-depth literature search was conducted using Ovid Medline and PubMed.

Results

The most active chemotherapeutic agents in sarcoma are anthracyclines and ifosfamide. Adjuvant chemotherapy trials show only minimal benefit. Neoadjuvant chemotherapy offers the potential advantage of reducing the extent of surgery, increasing the limb salvage

SUBMITTER: Nathenson MJ 

PROVIDER: S-EPMC7577379 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature