Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma.

ABSTRACT:

Background

We examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C.

Methods

We retrospectively analyzed 604 patients with HCC diagnosed between January 1999 and December 2015, and 288 patients without HCC who were seen at the National Hospital Organization Nagasaki Medical Center between October 2014 and November 2017. The association between serum kynurenine and prognosis was evaluated using the Cox's proportional hazards regression analysis.

Results

Patients with HCC had significantly higher values of serum kynurenine than patients without HCC (median: 557.1 vs. 464.2 ng/mL, p<0.001). Five-year survival

SUBMITTER: Bekki S 

PROVIDER: S-EPMC7577466 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature