Genomewide Expression Profiling Identifies a Novel miRNA-based Signature for the Detection of Peritoneal Metastasis in Patients With Gastric Cancer.

ABSTRACT:

Objective

This study aimed to conduct a genomewide transcriptomic profiling to develop a microRNA (miRNA)-based signature for the identification of peritoneal metastasis (PM) in patients with gastric cancer (GC).

Summary background data

Even though PM in patients with GC has long been recognized to associate with poor prognosis, currently there is lack of availability of molecular biomarkers for its robust diagnosis.

Methods

We performed a systematic biomarker discovery by analyzing miRNA expression profiles in primary tumors from GC patients with and without PM, and subsequently validated the expression of candidate miRNA biomarkers in 3 independent clinical cohorts of 354 patients with advanced GC.

Results

Five miRNAs (miR-30a-5p, -134-5p, -337-3p, -659-3p, a

SUBMITTER: Shimura T 

PROVIDER: S-EPMC7577555 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature