Artemisinin exposure at the ring or trophozoite stage impacts Plasmodium falciparum sexual conversion differently.

ABSTRACT: Malaria transmission is dependent on the formation of gametocytes in the human blood. The sexual conversion rate, the proportion of asexual parasites that convert into gametocytes at each multiplication cycle, is variable and reflects the relative parasite investment between transmission and maintaining the infection. The impact of environmental factors such as drugs on sexual conversion rates is not well understood. We developed a robust assay using gametocyte-reporter parasite lines to accurately measure the impact of drugs on sexual conversion rates, independently from their gametocytocidal activity. We found that exposure to subcurative doses of the frontline antimalarial drug dihydroartemisinin (DHA) at the trophozoite stage resulted in a ~ fourfold increase in sexual conversion. In c

SUBMITTER: Portugaliza HP 

PROVIDER: S-EPMC7577739 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature