The genetic map of diabetic nephropathy: evidence from a systematic review and meta-analysis of genetic association studies.

ABSTRACT: Despite the extensive efforts of scientists, the genetic background of diabetic nephropathy (DN) has not yet been clarified. To elucidate the genetic variants that predispose to the development of DN, we conducted a systematic review and meta-analysis of all available genetic association studies (GAS) of DN. We searched in the Human Genome Epidemiology Navigator (HuGE Navigator) and PubMed for available GAS of DN. The threshold for meta-analysis was three studies per genetic variant. The association between genotype distribution and DN was examined using the generalized linear odds ratio (OR_G). For variants with available allele frequencies, the examined model was the allele contrast. The pooled OR was estimated using the DerSimonian and Laird random effects model. The publicati

SUBMITTER: Tziastoudi M 

PROVIDER: S-EPMC7577775 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature