Adjuvant Chemotherapy in Microsatellite Instability-High Gastric Cancer.

ABSTRACT:

Purpose

Microsatellite instability (MSI) status may affect the efficacy of adjuvant chemotherapy in gastric cancer. In this study, the clinical characteristics of MSI-high (MSI-H) gastric cancer and the predictive value of MSI-H for adjuvant chemotherapy in large cohorts of gastric cancer patients were evaluated.

Material and methods

This study consisted of two cohorts. Cohort 1 included gastric cancer patients who received curative resection with pathologic stage IB-IIIC. Cohort 2 included patients with MSI-H gastric cancer who received curative resection with pathologic stage II/III. MSI was examined using two mononucleotide markers and three dinucleotide markers.

Results

Of 359 patients (cohort 1), 41 patients (11.4%) had MSI-H. MSI-H tumors were more frequently id

SUBMITTER: Kim JW 

PROVIDER: S-EPMC7577821 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature