Genetic Alterations in Preinvasive Lung Synchronous Lesions.

ABSTRACT:

Purpose

Despite advances in treatment, lung cancer remains the leading cause of cancer mortality. This study aimed to characterise genome-wide tumorigenesis events and to understand the hypothesis of the multistep carcinogenesis of lung adenocarcinoma (LUAD).

Materials and methods

We conducted multiregion whole-exome sequencing of LUAD with synchronous atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ, or minimally invasive adenocarcinoma of 19 samples from three patients to characterize genome-wide tumorigenesis events and validate the hypothesis of the multistep carcinogenesis of LUAD. We identified potential pathogenic mutations preserved in preinvasive lesions and supplemented the finding by allelic variant level from RNA sequencing.

Results

Overall,

SUBMITTER: Ahn S 

PROVIDER: S-EPMC7577825 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature