Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease.

ABSTRACT:

Objective

To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPS_CAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, and assess its interplay with the Pooled Cohort Equations (PCE) clinical risk estimator. Approach and Results: We studied GPS_CAD in 28 556 middle-aged participants of the Malmö Diet and Cancer Study, of whom 4122 (14.4%) developed CAD over a median follow-up of 21.3 years. A pronounced gradient in lifetime risk of CAD was observed-16% for those in the lowest GPS_CAD decile to 48% in the highest. We evaluated the discriminative capacity of the GPS_CAD-as assessed by change in the C-statistic from a baseline model including ag

SUBMITTER: Hindy G 

PROVIDER: S-EPMC7577949 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature