Unravelling the antimicrobial action of antidepressants on gut commensal microbes.

ABSTRACT: Over the past decade, there has been increasing evidence highlighting the implication of the gut microbiota in a variety of brain disorders such as depression, anxiety, and schizophrenia. Studies have shown that depression affects the stability of gut microbiota, but the impact of antidepressant treatments on microbiota structure and metabolism remains underexplored. In this study, we investigated the in vitro antimicrobial activity of antidepressants from different therapeutic classes against representative strains of human gut microbiota. Six different antidepressants: phenelzine, venlafaxine, desipramine, bupropion, aripiprazole and (S)-citalopram have been tested for their antimicrobial activity against 12 commensal bacterial strains using agar well diffusion, microbroth dilution metho

SUBMITTER: Ait Chait Y 

PROVIDER: S-EPMC7578019 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature