Manipulation of the gut microbiota by the use of prebiotic fibre does not override a genetic predisposition to heart failure.

ABSTRACT: Increasing evidence supports a role for the gut microbiota in the development of cardiovascular diseases such as hypertension and its progression to heart failure (HF). Dietary fibre has emerged as a modulator of the gut microbiota, resulting in the release of gut metabolites called short-chain fatty acids (SCFAs), such as acetate. We have shown previously that fibre or acetate can protect against hypertension and heart disease in certain models. HF is also commonly caused by genetic disorders. In this study we investigated whether the intake of fibre or direct supplementation with acetate could attenuate the development of HF in a genetic model of dilated cardiomyopathy (DCM) due to overexpression of the cardiac specific mammalian sterile 20-like kinase (Mst1). Seven-week-old male mice DC

SUBMITTER: Jama HA 

PROVIDER: S-EPMC7578080 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature