Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation.

ABSTRACT:

Background

The P-wave duration (PWD) is an electrocardiographic measurement that represents cardiac conduction in the atria. Shortened or prolonged PWD is associated with atrial fibrillation (AF). We used exome-chip data to examine the associations between common and rare variants with PWD.

Methods

Fifteen studies comprising 64 440 individuals (56 943 European, 5681 African, 1186 Hispanic, 630 Asian) and ≈230 000 variants were used to examine associations with maximum PWD across the 12-lead ECG. Meta-analyses summarized association results for common variants; gene-based burden and sequence kernel association tests examined low-frequency variant-PWD associations. Additionally, we examined the associations between PWD loci and AF using previous AF genome-wide association stud

SUBMITTER: Weng LC 

PROVIDER: S-EPMC7578098 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature