Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions.

ABSTRACT: T follicular helper (T_FH) cells are critical in adaptive immune responses to pathogens and vaccines; however, what drives the initiation of their developmental program remains unclear. Studies suggest that a T cell antigen receptor (TCR)-dependent mechanism may be responsible for the earliest T_FH cell-fate decision, but a critical aspect of the TCR has been overlooked: tonic TCR signaling. We hypothesized that tonic signaling influences early T_FH cell development. Here, two murine TCR-transgenic CD4⁺ T cells, LLO56 and LLO118, which recognize the same antigenic peptide presented on major histocompatibility complex molecules but experience disparate strengths of tonic signaling, revealed low tonic signaling promotes T_FH cell differentia

SUBMITTER: Bartleson JM 

PROVIDER: S-EPMC7578106 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature