Change over time in ability to perform activities of daily living in myotonic dystrophy type 1.

ABSTRACT:

Objective

The objective of this longitudinal, observational study was to investigate change over time in ability to perform activities of daily living in myotonic dystrophy type 1 (DM1).

Methods

Adults with genetically confirmed DM1 were recruited as part of the PhenoDM1 study in the UK. Data on activities of daily living were recorded through the DM1-Activ^C at baseline and a follow-up visit after 12 (± 3) months. A subset of patients had advanced genetic testing to determine the size of the progenitor allele.

Results

Our sample comprised 150 patients with DM1 (mean age: 45 years; 52% female). Mean follow-up was 383 days. Mean DM1-Activ^C total score at baseline was 71.24 (95% confidence interval 67.77-74.71) and at the follow-up visit 69.04 (65.5

SUBMITTER: Landfeldt E 

PROVIDER: S-EPMC7578145 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature