Genetic and epigenetic analyses of panic disorder in the post-GWAS era.

ABSTRACT: Panic disorder (PD) is a common and debilitating neuropsychiatric disorder characterized by panic attacks coupled with excessive anxiety. Both genetic factors and environmental factors play an important role in PD pathogenesis and response to treatment. However, PD is clinically heterogeneous and genetically complex, and the exact genetic or environmental causes of this disorder remain unclear. Various approaches for detecting disease-causing genes have recently been made available. In particular, genome-wide association studies (GWAS) have attracted attention for the identification of disease-associated loci of multifactorial disorders. This review introduces GWAS of PD, followed by a discussion about the limitations of GWAS and the major challenges facing geneticists in the post-GWAS era

SUBMITTER: Morimoto Y 

PROVIDER: S-EPMC7578165 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature