System biological investigations of hydroxychloroquine and azithromycin targets and their implications in QT interval prolongation.

ABSTRACT: COVID-2019 pandemic is affecting people worldwide in the absence of an effective treatment strategy. Several suggestive therapeutic options through drug repurposing are recommended, but a complete consensus is not reached. A combination of Hydroxychloroquine (HCQ) and Azithromycin (AZM) has been widely tried and discussed but its administration has also led to potential adversities in patients. Studies are suggesting that most prominent adverse event with HCQ and AZM combination is QT interval prolongation. We studied interaction of HCQ with AZM and subsequent effect of this drug combination on QT interval prolongation. We performed system biological investigation of HCQ and AZM targets and screened important targets and pathways possibly involved in QT interval prolongation. The best core

SUBMITTER: Khan AA 

PROVIDER: S-EPMC7578186 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature