SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs.

ABSTRACT: Significance: Sulfur has a critical role in protein structure/function and redox status/signaling in all living organisms. Although hydrogen sulfide (H₂S) and sulfane sulfur (SS) are now recognized as central players in physiology and pathophysiology, the full scope and depth of sulfur metabolome's impact on human health and healthy longevity has been vastly underestimated and is only starting to be grasped. Since many pathological conditions have been related to abnormally low levels of H₂S/SS in blood and/or tissues, and are amenable to treatment by H₂S supplementation, development of safe and efficacious H₂S donors deserves to be undertaken with a sense of urgency; these prodrugs also hold the promise of becoming widely used for

SUBMITTER: Gojon G 

PROVIDER: S-EPMC7578191 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature