Brown adipose tissue uptake of triglyceride-rich lipoprotein-derived fatty acids in diabetic or obese mice under different temperature conditions.

ABSTRACT:

Background

In vivo imaging of glucose analogue 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) via positron emission tomography (PET) is the current gold standard to visualize and assess brown adipose tissue (BAT) activity. However, glucose metabolism is only a part of the metabolic activity of BAT. [¹⁸F]FDG-PET has been shown in clinical trials to often fail to visualize BAT under insulin-resistant conditions associated with aging and weight gain. We employed a novel developed triglyceride-based tracer to visualize BATs metabolic activity under different temperature conditions as well as under diabetic and obese conditions in preclinical models.

Results

[¹⁸F]BDP-TG-chylomicron-like particles visualized BAT in control, streptozocin-indu

SUBMITTER: Paulus A 

PROVIDER: S-EPMC7578207 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature