Respiratory viral coinfection in a birth cohort of infants in rural Nepal.

ABSTRACT:

Background

Acute respiratory illnesses are a leading cause of global morbidity and mortality in children. Coinfection with multiple respiratory viruses is common. Although the effects of each virus have been studied individually, the impacts of coinfection on disease severity are less understood.

Methods

A secondary analysis was performed of a maternal influenza vaccine trial conducted between 2011 and 2014 in Nepal. Prospective weekly household-based active surveillance of infants was conducted from birth to 180 days of age. Mid-nasal swabs were collected and tested for respiratory syncytial virus (RSV), rhinovirus, influenza, human metapneumovirus (HMPV), coronavirus, parainfluenza (HPIV), and bocavirus by RT-PCR. Coinfection was defined as the presence of two or more resp

SUBMITTER: Emanuels A 

PROVIDER: S-EPMC7578290 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature