Hepatic osteodystrophy and fracture risk prediction using FRAX tool in Indian patients with cirrhosis.

ABSTRACT:

Background and aim

The main clinical relevance of hepatic osteodystrophy is the increased risk of fractures. Dual-energy X ray absorptiometry (DEXA)-based assessment of bone mineral density, the current gold standard for diagnosing osteoporosis, is not the sole determinant of fracture risk. Other clinical risk factors also play an important role. This study was carried out to assess the prevalence and risk factors of hepatic osteodystrophy and estimate the entailed fracture risk by using the FRAX tool in a cohort of Indian cirrhotics.

Methods

Consecutive patients with cirrhosis (n = 120) were recruited. Etiologic workup, liver function tests, serum calcium, phosphate, 25(OH)D, HbA1c, and DEXA scan were performed. Hepatic osteodystrophy was defined as a T score of < -1

SUBMITTER: De A 

PROVIDER: S-EPMC7578334 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature